An appreciation of Ralph Marvin Steinman (1943–2011)
نویسنده
چکیده
Ralph Steinman, an editor at the Journal of Experimental Medicine since 1978, shared the 2011 Nobel Prize in Physiology or Medicine for his discovery of dendritic cells (DCs) and their role in immunity. Ralph never knew. He died of pancreatic cancer on September 30, 3 days before the Nobel announcement. Unaware of his death at the time of their announcement, the Nobel Committee made the unprecedented decision that his award would stand. Ralph was the consummate physician-scientist to the end. After his diagnosis, he actively participated in his 4.5 years of treatments, creating experimental therapies using his own DCs in conjunction with the therapies devised by his physicians, all the while traveling, lecturing, and most of all pursuing new investigations in his laboratory. For 38 years—from his discovery of DCs to his Nobel Prize—Ralph pioneered the criteria and methods used to identify, isolate, grow, and study DCs. He and his colleagues demonstrated that DCs are initiators of immunity and regulators of tolerance. In his most recent studies, Ralph was harnessing the specialized features of DCs to design improved vaccines. The following synopsis describes some of his seminal discoveries.
منابع مشابه
Ralph M. Steinman 1943–2011
Ralph M. Steinman, professor of immunology at The Rockefeller University in New York and one of the great immunologists of our time, died on September 30 after a long fight with pancreatic cancer, just three days before the announcement that he had been awarded the Nobel Prize in Physiology or Medicine for the discovery of the dendritic cell. Steinman is universally recognized for having given ...
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This issue of the Journal of Experimental Medicine celebrates and honors the life of Ralph Steinman (1943-2011), winner of the 2011 Nobel Prize in Physiology or Medicine. Ralph's science was rooted in fundamental discovery with the goal of translating these findings into clinical medicine. He recognized the power of immunology in treating human disease and passionately championed studies on vac...
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متن کاملA tribute to Ralph M. Steinman.
Ralph Marvin Steinman, the pioneering immunologist and discoverer of dendritic cells — pivotal cells that initiate and regulate the body’s immune response — passed away on September 30, 2011, just three days before it was announced that he was to be awarded the 2011 Nobel Prize in Physiology or Medicine (Figure 1). Ralph was born on January 14, 1943, in Montreal, the second of four siblings. Af...
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عنوان ژورنال:
دوره 208 شماره
صفحات -
تاریخ انتشار 2011